(P25-036-25) Hospital-Wide vs. ICU Risk of CLABSI in Patients Receiving Parenteral Nutrition: A Retrospective Multisite Study

Objectives: Despite advances in prevention, central line-associated bloodstream infection (CLABSI) represents a significant healthcare concern, contributing to increased patient morbidity and mortality as well as rising healthcare costs. Prior observational studies have demonstrated that parenteral nutrition (PN) is associated with a small but statistically significant increase in incidence of CLABSI. The objective of this study is to provide an updated description of the relationship between PN and CLABSI along with an evaluation of risk factors.

Methods: A retrospective observational study was conducted using data from adult patients admitted between June 1, 2020 and July 31, 2024 to two affiliated hospitals in a large academic health system in New York City. Univariate and multivariate analyses were performed to examine the relationship between PN and CLABSI risk, with additional subgroup analysis focusing on patients in intensive care units (ICU).

Results: During the study period, 25,502 patient admissions were associated with a central venous catheter (CVC). Among these patients, 186 CLABSIs were documented. PN administration was associated with a higher risk of CLABSI when adjusting for confounders (OR 2.153; 95% CI, 1.282–3.616). However, subgroup analysis of ICU patients demonstrated that PN was not a significant risk factor for CLABSI.

Conclusions: PN is associated with an increased risk of CLABSI hospital-wide but not in ICU patients, suggesting context-dependent risk. Further work is needed to determine effective strategies for reducing rates of CLABSI among patients receiving PN and to validate these findings in broader patient populations.

Funding Sources: This research was supported by Columbia University Student Research at the Vagelos College of Physicians and Surgeons (VP&S) and the Columbia University Irving Institute for Clinical and Translational Research.