(P26-058-25) Supplementation of Griffonia simplicifolia and a Mushroom Blend Positively Influence Mood and Sleep Quality in Young Adults

Objectives: This study evaluated the potential efficacy of supplementation of capsule or functional food (snack bar) delivery of commercially available organic Griffonia simplicifolia extract (5-HTP) (GS), and organic mushroom extract blend (MB) of Ganoderma lucidum (Reishi mushroom), Cordyceps militaris, Hericium erinaceus (Lion’s Mane), and fermented Cordyceps Sinesis mycelium in improving mood and sleep quality and measurement of salivary cortisol.

Methods: Young adults (aged 18-40 years) experiencing mood states of sadness and anxiousness, as well as poor sleep quality, were randomly assigned to one of six groups (n=20/group) to receive either capsule (CAP) or snack bar (BAR) delivery form of either placebo (PLA), 125mg MB (MB-CAP or MB-BAR), or 75mg GS (GS-CAP or GS-BAR) twice per day for 25 days. Participants were assessed for mood and sleep quality via DASS-21 and PSQI respectively between groups on Day 0 (baseline) and Days 13 and 25, as well as salivary cortisol at baseline and Day 25.

Results: Compared to PLA, GS and MB supplementation showed a positive change in mood states (e.g., sadness, anxiousness, and stress) (p < 0.05) and sleep quality (p < 0.05) at Days 13 and 25, as well as change in salivary cortisol levels (p < 0.0001) at Day 25.

Conclusions: It is concluded that supplementation with organic Griffonia simplicifolia extract (5-HTP) and organic mushroom extract blend can positively influence mood, sleep, and cortisol levels for young adults experiencing disturbances.

Funding Sources: This study was sponsored by NURA USA LLC, Irvine CA, USA.