(P20-041-25) Nutritional Modulation of Lipid Profiles by Andrographis paniculata Aqueous Leaf Extract in Statin-Treated Wistar Rats

Objectives: Andrographis paniculata, (AP) also known as king of bitters is a medicinal plant native to Nigeria, India and Sri lanka with numerous health benefits. The leaves extract of AP have been used as a traditional remedy in treating infections, fever, colic pain, loss of appetite, common cold, hypertension, diabetes, cancer, malaria, and diarrhea. This fourteen (14) days research work was designed to investigate the Nutritional modulation of oral administration of hot water extract of AP leaf on lipid profile parameters of male albino rats treated with statin.

Methods: Exactly 60 rats weighing between 170-210g were grouped into 6 cages of 10 rats each. Groups 1 and 2 were the normal control (given n-saline) and positive control (administered statin), groups 3 and 4 were administered 250mg/kg and 500mg/kg of the extract while groups 5 and 6 were administered statin and 250mg/kg and 500mg/kg of the AP extract respectively for fourteen days. Water and Food were given ad libitum. The lipid profile analyzed were Total cholesterol (TC), High Density Lipoprotein (HDL-C), Low Density Lipoprotein (LDL-C), Triglycerides (TG), and Very Low Density Lipoprotein (VLDL) .

Results: Comparing the control group on HDL-C (37.00± 0.05) and VLDL (23.93±0.01), with the AP treated groups, a non significant (p >0.05) difference was recorded at 250mg/kgAP and 500mg/kgAP for HDL-C (35.67±0.01 and 35.67±0.02) and VLDL (21.27±0.05 and 19.47±0.04) respectively. The 500mg/kgAP group on TC (132.67±0.07), TG (97.33±0.03) and LDL( 77.33±0.03) decreased significantly (p < 0.05) when compared to the control group (176.67±0.10, 119.67±0.01 and 118.00±0.02) respectively. Statin alone showed a statistical significant decrease (P < 0.05) in TC (154.67±0.03), TG (117.33±0.06) and LDL (92.64±0.05) when compared with the control (176.67±0.10, 119.67±0.01 and 118.00±0.02) respectively.

Statin + 250mg/kg AP group (37.33±0.04) and Statin + 500mg/kg AP group (37.33±0.02) showed a slight increase in HDL-C levels though not statistically significant (p >0.05) compared with the control group (37.33±0.05) and Statin alone treated group (36.67±0.02) but also elicited a statistical significant (P < 0.05) decrease on TC, TG, and LDL-C.

Conclusions: The available evidence suggests that Andrographis paniculata may be a useful adjunct to statin therapy in managing cholesterol levels.

Funding Sources: None