(P20-020-25) Intermittent Fasting and Protein Pacing Adherence Maintains 100 Pound Weight Loss for Two Years: A Case Study

Objectives: To document “real-world” adherence to the long-term success of IF-P, independent of structured physical exercise, during a two-year follow-up on a 100-pound case study participant.

Methods: A sixty-one-year-old male (174.1 cm; 162.7 kg; 47.4% fat at baseline) followed IF (~500 kcals/day, 1-2 days/week) and P (4 meals/day, containing 35-50 grams of protein, 1800 kcals/day, 5-6 days/week) for 2 years. Body weight (BW), waist circumference (WC), body composition, macronutrient intake, physical activity (PA), cardiometabolic endpoints (glucose, GLU; total cholesterol (TC); LDL-C; triglycerides (TG); and hunger ratings were measured at baseline, 1-year, and 2-years.

Results: Following 1 year of IF-P, significant decreases in BW (162.7 vs. 116.3 kg), WC (151.5 vs. 112 cm), % body fat (%BF) 47.4 vs. 35.7 %), fat mass (FM, 75.8 vs. 41.6 kg), fat-free mass (FFM, 81.5 vs. 74.9), FFM/BW (0.51 vs. 0.65), and visceral fat mass (VFM, 5.8 vs. 1.96 kg) were observed. Systolic/diastolic blood pressure (SBP/DBP) also decreased (146/94 vs. 133/80 mm/Hg), as did plasma markers: TC (164 vs. 152 mg/dL), LDL-C (96 vs. 85 mg/dL), TG (93 vs. 45 mg/dL), HDL-C (49 vs. 58 mg/dL), GLU (141 vs. 89 mg/dL). Hunger ratings decreased by 39%-67%. Similar favorable reductions were continued or maintained after year 2: (BW, 118.4 kg; WC, 115.0; %BF, 37.5%; FM, 43.2 kg; FFM, 75.4 kg; FFM/BW, 0.64; VFM, 2.35 kg; SBP/DBP, 146/81 mm/Hg; TC, 172 mg/dL; LDL-C, 94 mg/dL; TG, 45 mg/dL; HDL-C, 69 mg/dL, GLU, 92 mg/dL; hunger ratings, -25-55%. No changes in PA were determined (baseline, 593.6; 1 year, 648; 2 years, 790 kcals/day). At baseline, the subject consumed 3366.2 kcals/day compared with ~1800 kcals/day during P days and ~500 kcals/day during IF days at 1- and 2 years, demonstrating adherence to the intervention.

Conclusions: Our findings support IF-P as a “real-world” lifestyle strategy to initiate significant weight loss ( > 45 kgs / 100 lbs.) and, more importantly, allow for successful weight loss maintenance, cardiometabolic benefits, and satiety for a prolonged duration.

Funding Sources: Isagenix International, LLC to PJA.