(P02-080-25) Evaluation of Antibiotic Residual Concentration and the Effects in Broiler Chicks

Objectives: The rise of antibiotic resistance has become a significant global health concern. This has pose serious threats  to public health, agriculture and biosecurity. Often due to the misuse antibiotic leading to the emergence of resistant strains.

Methods: A 100 questionnaire survey on antibiotics usage were distributed to industrial poultry farmers in Keffi, Nigeria. Antibiotics mostly used as growth promoters and for therapeutic effects on birds were discovered. Seven  of the most used antibiotics were administered for 4 weeks, were grouped into 7 of 50 chicks. each (Ao 400mg/kg; Bt 500mg/kg; Cg 330mg/kg; Dp 500mg/kg; En 220mg/kg; Fs 200mg/kg; Gf 300mg/kg. The ontrol group 8 were with no antibiotic; group 9 were purchased from poultry farms and group 10 were purchased from Open-market respectively and all animal in the group were average of 4 weeks old with 50 chicks in a group. Blood, breast, gizzard and crop samples were collected. HPTLC plate and UV lamp were used to determine the residual antibiotic concentrations. The liver, enzymes, kidney function tests and hematological parameters, antibiotic sensitivity microbial screening and tissue culture tests wee evaluated.

Results: The result showed that group 9 and 10 had adverse results with a significant difference (p < 0.05) in kidney, liver and hematological parametters compared to groups 1,2,3,4,5,6,7 and 8. The group 9 and 10 showed a significant difference (p < 0.05) with exceeding concentration of the recommended antibiotic residue limits in breast and liver samples compared to other groups. Pathogenic resistant bacteria like Salmonella spp and E.coli were found in groups 9 and 10 crop and gizzard samples.

Conclusions: The misuse of antibiotics as growth promoters and therapeutics, may affect the liver, kidney and blood of chicks, exceeds antibiotic residues limit and also contribute to the development of antibiotic resistant bacteria. This may render the chicken unsafe for human consumption.

Funding Sources: There is no funding for this research. Is just an Institution (Nasarawa State University, Keffi, Nigeria funded research.