Dominique R. Williams, MD, MPH: Abbott Nutrition: Employee (Ongoing)
Scientific conference where the work was recently presented: ObesityWeek 2024
Date on which the work was previously presented at the scientific conference listed: November 3, 2024
Objectives: A retrospective observational study was designed to examine the association between low vitamin D (LVD) and high C-reactive protein (HCRP) with occurrence of diabetes (DM) in adults 50 and older with overweight/obesity using the data from the University of Michigan Health and Retirement Study.
Methods: All variables were analyzed using logistic regression with the model factors Age at 2016 Survey, Gender, Race/Ethnicity, Highest Degree of Education, LVD, HCRP, and LVD × HCRP. Five comparisons were tested for each variable: 1) LVD: Yes vs. No; 2) HCRP: Yes vs. No; LVD and HCRP: 3) Yes Yes vs. Yes No, 4) Yes Yes vs. No Yes, and 5) Yes Yes vs. No No. The P values were adjusted for multiple testing using adaptive Holm method. All hypothesis tests were performed using 2-sided, 0.05 level tests.
Results: For the variable “Has a doctor ever told you that you have diabetes, borderline diabetes, or pre-diabetes?” in 2022 survey among those who answered “No” to the question in 2016 survey, the odds of responding “Yes” to the question for those with LVD and HCRP were 1.64 (95% confidence interval for odds ratio and P value: 1.00-2.68, P=0.048) times as high as those without LVD and HCRP.
For the variable DM occurrence (HbA1c ≥ 6.5%) in 2016 survey, the odds of DM for those with LVD were 2.02 (1.38-2.96, P < 0.001) times as high as those without LVD. The odds of DM for those with LVD and HCRP were 1.69 (1.08-2.63, P=0.045) times as high as those without LVD and with HCRP. The odds of DM for those with LVD and HCRP were 2.83 (1.66-4.83, P < 0.001) times as high as those without LVD and HCRP.
Conclusions: There was an association between LVD, HRCP and risk of DM in adults with overweight/obesity. Combined nutrient levels and inflammation may play a role in risk of chronic disease.
Funding Sources: This research was not funded by a grant from any funding agencies. As employees of Abbott Laboratories, DW and YC receive salaries for their professional responsibilities.
