(P25-017-25) Personalized Parenteral Nutrition on Inflammation, Nutritional Status and Clinical Recovery in Critically Ill Patients: A Systematic Review and Meta-analysis

Objectives: The study aimed to provide a systematic meta-analysis on Personalized Parenteral Nutrition (PPN) with the aim to providing direction to future studies that will set a standard guideline for the use of PPN on Inflammation, Nutritional Status and Clinical Recovery in Critically Ill Patients.

Methods: A systematic literature search was conducted in PubMed, EMBASE, and Cochrane databases. Included studies were those that had assessed the diagnostic accuracy or clinical outcomes of Personalized Parenteral Nutrition (PPN) in critically ill patients. The results of eligible studies were pooled through meta-analysis.

Results: The meta-analysis included 7 studies. The study observed that PPN achieved moderate to high diagnostic accuracy at a pooled sensitivity value of 0.63 (95% CI: 0.56-0.69), as well as a value at the pooled specificity of 0.85 (95% CI: 0.81-0.88).  This meta-analysis of observational studies was inconsistent when regarding the clinical effect of PPN on mortality, morbidity, and length of stay. The pooled hazard ratio for mortality was (CI 95%), suggesting potential risk between PPN and mortality. However, significant heterogeneity amongst these studies makes this relationship far from simple.

Conclusions: PPN has the potential to improve outcomes in critically ill patients, but optimal use and clinical impact remain uncertain. Future research is needed to refine the diagnostic criteria, optimize the composition of PPN formulations, and evaluate long-term effects of this intervention.

Funding Sources: N/A