(P22-056-25) Association Between Sleep Quality and Cardiovascular Disease Risk Factors in Middle-Aged and Older Population in Singapore

Objectives: Cardiovascular disease (CVD) is a leading cause of death globally, with poor sleep quality linked to increased risk. As people age, sleep quality tends to decline, potentially elevating CVD risk. However, more research is needed to understand the specific impact of sleep quality on cardiovascular health in older adults. The aim of this study was to assess the association between sleep quality and CVD risk in middle-aged and older adults in Singapore.

Methods: In this cross-sectional study, 108 middle-aged and older adults (mean age 66 ± 4 years) were recruited. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), with the Global Sleep Score (GSS) calculated for each participant. CVD-related parameters, including blood lipid-lipoprotein profiles, blood pressure, and Framingham risk scores, were assessed. The relationships between sleep quality and CVD outcomes were analyzed using multiple linear regression, adjusted for age and BMI.

Results: A negative association was found between the GSS and systolic blood pressure (β-coefficient = -1.150, p = 0.043), indicating that better sleep quality (lower GSS) is associated with lower systolic blood pressure. No other significant associations were observed between sleep quality and the assessed CVD-related parameters.

Conclusions: In conclusion, this study suggests that better sleep quality may be associated with improved cardiovascular health, particularly in relation to blood pressure management. Further research is needed to clarify the underlying mechanisms and explore potential interventions targeting sleep quality for cardiovascular risk reduction.

Funding Sources: National University of Singapore (Grant number: R-143-000-A03-133)