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Aging and Chronic Disease (Poster Session)

(P22-069-25) The Impact of L-Ergothionein Supplementation on the Efficacy of Collagen Peptides and Hyaluronic Acid Complexes

Monday, June 2, 2025
11:45 AM - 12:45 PM ET
Location: Poster Board B-96

    Presenting Author(s)

  • Hua Zhang, Ph.D.

    Senior Manager
    H&H Group
    Guangzhou, Guangdong, China (People's Republic)

    • Co-Author(s)

  • LW

    Lotus Wong

    H&H Group

  • Lei Chen (she/her/hers)

    Senior researcher
    Health and Happiness (H&H) China Limited
    Guangzhou, Guangdong, China (People's Republic)

  • QL

    Qiying Liang

    Health and Happiness (H&H) China Limited
    Guangzhou, Guangdong, China (People's Republic)

  • JH

    Jingya Huang

    H&H Group
    Guangzhou, Guangdong, China (People's Republic)

  • LZ

    Lynn Zhao

    H&H Group

Disclosure(s):
Lei Chen: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: Ultraviolet (UV) radiation and natural aging induce the production of free radicals in skin cells, which can migrate to melanocytes, enhancing melanin synthesis and causing skin dullness. Additionally, free radicals disrupt redox homeostasis, leading to collagen degradation, skin dehydration, and wrinkle formation. Previous studies have demonstrated the benefits of collagen peptides and hyaluronic acid supplementation for skin health, and the significant antioxidant properties of L-ergothioneine. However, the combined effects of L-ergothioneine with collagen peptides and hyaluronic acid remain unexplored. This study aims to evaluate the synergistic potential of these three ingredients on skin health using a zebrafish model.

Methods: The zebrafish model was employed to assess the effects of L-ergothioneine, collagen peptides, and hyaluronic acid (ECH) on skin health indicators, including anti-photoaging, anti-inflammation, anti-aging, and skin elasticity, compared to collagen peptides and hyaluronic acid (CH) alone. Statistical analysis was conducted using ANOVA, with significance set at P< 0.05.

Results: The ECH combination demonstrated significant improvements over CH in several parameters. Anti-inflammatory effects were evidenced by the relative expression of il-17a/f3, il-6, and il-10 genes. Skin elasticity was enhanced, as indicated by the expression of col1a1a, col1a1b, and eln2 genes. Anti-photoaging effects were observed through reduced reactive oxygen species (ROS) levels, and anti-aging effects were confirmed by decreased β-galactosidase staining intensity.

Conclusions: The findings suggest that the ECH formula offers superior protection against skin aging, including photoaging and inflammation, compared to CH alone. This study highlights the potential of L-ergothioneine in combination with collagen peptides and hyaluronic acid to improve skin health.

Funding Sources: H&H Group