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Neuroscience/Nutrition and the Brain (Poster Session)

(P09-037-25) Coffee and Tea Intake, Circulating Inflammatory Biomarkers, and Long-Term Risk of Dementia: Findings From Two Longitudinal Studies

Saturday, May 31, 2025
11:45 AM - 12:45 PM ET
Location: Poster Board D-36

    Presenting Author(s)

  • MY

    Minqing Yan, Bachelor

    Student
    Zhejiang University
    Hangzhou, Zhejiang, China (People's Republic)

    • Co-Author(s)

  • JS

    Jie Shen, n/a

    PhD student
    Zhejiang University
    Hangzhou, Zhejiang, China (People's Republic)

  • Mengjia Zhao, MPH

    866, Yuhangtang Road, Hangzhou, China 310058
    The Second Affiliated Hospital, Zhejiang University School of Medicine, School of Public Health
    Hangzhou, Zhejiang, China (People's Republic)

  • LF

    Leqi Fei

    Zhejiang University School of Medicine, China (People's Republic)

  • YH

    Yuhui Huang

    Zhejiang University, China (People's Republic)

  • MW

    Minyu Wu, Ph.D.

    Postdoctoral fellow
    School of Public Health of Zhejiang University, China (People's Republic)

  • TS

    Ting Shen

    Zhejiang University
    Hangzhou City, Zhejiang, China (People's Republic)

  • GH

    Gulisiya Hailili, Public health physician qualification certificate

    Zhejiang University School of Medicine
    hangzhou, Zhejiang, China (People's Republic)

  • GZ

    Geng Zong

    CAS Key Laboratory of Nutrition, China (People's Republic)

  • YZ

    Yan Zheng

    Fudan University, China (People's Republic)

  • DH

    Dong Hang

    School of Public Health, Gusu School, Nanjing Medical University, Nanjing, China

  • CY

    Changzheng Yuan, ScD

    School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

Disclosure(s):
Minqing Yan, Bachelor: No relevant financial relationship(s) with ineligible companies to disclose.
Mengjia Zhao, MPH: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: We aimed to evaluate the associations of coffee and tea intake with incident dementia and assess the potential mediating role of the circulating inflammatory biomarkers in the corresponding associations.

Methods: We included 6,001 participants free of dementia at study baseline from the Health and Retirement Study (HRS, 2013-2020) and 2,650 participants from the Framingham Heart Study Offspring cohort (FOS, 1998-2018). Coffee and tea intake was assessed using a semi-quantitative food frequency questionnaire in both cohorts. Dementia diagnosis was ascertained using a validated algorithm and clinical review panel. Cox proportional hazard models were used for each cohort to evaluate the associations of coffee and tea intake with dementia, and mediation analysis was conducted to assess whether the corresponding association was mediated by circulating inflammatory biomarkers.

Results: During a median follow-up of 7.0 years in HRS and 11.1 years in FOS, 231 individuals in HRS and 204 in FOS developed all-cause incident dementia. As compared with participants who drank less than 1 cup/day of coffee, those who drank ≥2 cups/day were associated with 28%-36% lower risk of dementia (Hazards ratio [HR] = 0.72, 95% confidence interval [CI]: 0.53-0.99, P-trend = 0.046 for HRS; HR = 0.64, 95% CI: 0.45-0.91, P-trend = 0.019 for FOS). In terms of tea intake, compared to individuals who did not drink tea, moderate tea drinkers had a lower dementia risk in HRS (HR = 0.63, 95% CI: 0.46-0.86 for >0 to < 1 cup/day; HR = 0.53, 95% CI: 0.30-0.95 for ≥1 to < 2 cups/day), while no significant association was observed in FOS. In the mediation analysis, the association between coffee intake and dementia was partially mediated by albumin (proportion = 29.46%), Cystatin C (17.24%), interleukin-10 (IL-10, 16.74%), C-reactive protein (CRP, 13.74%), and soluble tumor necrosis factor receptor-1 (sTNFR-1, 9.54%).

Conclusions: Higher consumption of coffee is associated with a lower risk of incident dementia, which is partially mediated by a panel of inflammatory biomarkers. Moderate intake of tea may relate to lower risk of dementia. Further large-scale observational and interventional studies are warranted to confirm these findings.

Funding Sources: None