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Clinical Nutrition (Poster Session)

(P25-028-25) The Effects of an Oral Synbiotic vs a Myo-Inositol Based Supplement in Those With Noncystic Acne

Monday, June 2, 2025
12:45 PM - 1:45 PM ET
Location: Poster Board D-81

    Presenting Author(s)

  • Jessica Maloh, ND

    Head of Naturopathic Medicine
    Codex Labs Corp
    San Jose, California, United States

    • Co-Author(s)

  • MM

    Mildred Min

    Integrative Skin Science and Research; Integrative Research Institute; California Northstate University - College of Medicine, United States

  • NA

    Nasima Afzal

    Integrative Skin Science and Research; Integrative Research Institute, United States

  • NA

    Nabeel Ahmad

    Integrative Skin Science and Research; Integrative Research Institute; University of Houston - College of Medicine, United States

  • DP

    David Pinzauti, PhD

    The Bio Arte Limited - Laboratories at Life Science Park, United States

  • BP

    Barbara Paldus, PhD

    Codex Labs Corp, United States

  • RS

    Raja Sivamani, MD MS AP

    Adjunct Associate Professor of Clinical Dermatology
    Integrative Skin Science and Research, Pacific Skin Institute, University of California-Davis, California Northstate University
    Sacramento, California, United States

Disclosure(s):
Jessica Maloh, ND: Codex Labs Corp: Advisory Committee/Board Member (Ongoing); Consultant (Ongoing); Stock Shareholder (excluding mutual funds) (Ongoing)


Objectives: To compare the effect of an oral synbiotic supplement vs a myo-inositol based supplement on inflammatory and non-inflammatory acne lesion counts.

Methods: Males and females between the ages of 12 to 45 years old with mild-to-moderate noncystic acne were randomized to receive an oral synbiotic or a myo-inositol based herbal supplement (MBHS) for 8 weeks. Acne lesion counting was performed by a board-certified dermatologist at baseline, 4, and 8 weeks.

Results: At week 4, inflammatory lesion counts decreased by 44.6% (p < 0.0001) in the synbiotic group and 55.2% (p < 0.0001) in the MBHS group, relative to baseline. At week 8, non-inflammatory lesion counts decreased by 58.2% (p < 0.0001) and 61.1% (p < 0.001) in the synbiotic and MBHS, respectively relative to baseline.

With regards to non-inflammatory lesions, there was a 29.1% (p < 0.0001) reduction in the synbiotic group and 28.6% (p < 0.0001) reduction in the MBHS group at week 4 relative to baseline. At week 8, inflammatory lesion counts decreased by 49.2% (p < 0.0001) and 62.1% (p < 0.0001) in the synbiotic and MBHS, respectively.

Conclusions: The results of this study suggest that an oral synbiotic or a myo-inositol based herbal supplement can significantly improve inflammatory and non-inflammatory lesions in those with noncystic acne.

Funding Sources: Codex Labs Corp