(P25-025-25) A Survey on Sarcopenia and Influencing Factors Among Peritoneal Dialysis Patients in China

Objectives: Sarcopenia is one of the common complications of peritoneal dialysis (PD). Physical activity is one of the important factors resulting in sarcopenia. However, previous studies rarely considered the impact of physical activity on sarcopenia in PD patients. Therefore, the study aimed to investigate the risk factors for the prevalence of sarcopenia in PD patients based on physical activity and clinical follow-up data.

Methods: A cross-sectional survey was conducted from February 2023 to February 2024 among PD patients in a tertiary hospital in eastern China. Routine dialysis monitoring indicators of patients and their participation in physical activity were collected. The low physical activity questionnaire was used to assess the level of physical activity. The diagnosis of sarcopenia was based on the criteria in Asian Working Group for Sarcopenia 2019. Binary logistic regression analysis was applied.

Results: A total of 830 patients were recruited, and 643 completed the survey. The average age was 48.04±12.77 years. Among them, 81 patients had sarcopenia, with a prevalence rate of 12.60%. The prevalence of PD sarcopenia was related to age (OR=1.043, 95%CI 1.015-1.074, P< 0.01), BMI(OR=0.614, 95%CI 0.541-0.689, P< 0.01) and parathyroid hormone (OR=3.198, 95%CI 1.808-5.690, P< 0.01), Charlson comorbidities index (OR=1.303, 95%CI 0.992-1.685, P=0.05), total consumption of PA in one week (OR=0.987, 95%CI 0.975-0.998, P< 0.05) .

Conclusions: The prevalence of sarcopenia among PD patients is influenced by old age, low BMI, more comorbidities, high parathyroid hormone, and low level of physical activity.Physicians should attach importance to the early screening of sarcopenia. It is recommended to carry out nutrition and exercise education for PD patients with high risks.

Funding Sources: National Natural Science Foundation of the People’s Republic of China