(P20-018-25) Feasibility and Acceptable of TRE With Aerobic or Resistance Exercise in Older Adults With Obesity and Pre-diabetes

Objectives: Obesity combined with age related decreases in lean mass and increases in fat mass leads to metabolic consequences such as decreased peripheral insulin sensitivity and pre-diabetes, increasing the risk of type 2 diabetes. Current treatment for obesity and pre-diabetes in older adults includes weight management and regular exercise, however, many individuals are unable to achieve success with traditional calorie restriction. Time restricted eating (TRE) is a form of intermittent fasting where individuals shorten the window in which they eat daily. Current trials combining TRE with exercise are limited to lean, active, young adults, yet TRE with either resistance training (RT) or aerobic training (AT) may to result in weight loss while maintaining learn mass in older adults. This pilot study was conducted to assess feasibility and acceptability 8-h TRE combined with RT or AT in older adults with prediabetes and obesity.

Methods: We implemented a 12-week parallel arm randomized trial. Participants were randomized to 4 days a week of either RT or AT and self-selected one of four eating windows which they maintained throughout the trial (10AM-6PM, 11AM-7PM, or 12-9PM).

Results: Most participants self-selected 12-8PM for their 8-hour eating window. Participants were adherent ~5 days/week to the 8-hour window and significantly decreased their eating window from baseline. There was no difference between groups in adherence to weekly intervention meetings or exercise sessions. Body weight, BMI, and fat mass decreased significantly in both groups from baseline, but fat free mass remained unchanged. Both groups experienced decreases in insulin and HOMA-IR, and increases in glucose, QUICKI, and HbA1c; however, none of these changes were statistically significant.

Conclusions: We show here that 8-hour time restricted eating with aerobic training or resistance training is feasible and acceptable in older adults with pre-diabetes and obesity and may improve body composition and insulin sensitivity.

Funding Sources: National Institutes of Health: Office of Research on Women's Health and National institute on Aging