(P17-011-25) Inflammatory Attenuation and Impacts on Relied Non-Communicable Diseases by a 10-wk Lifestyle-Changing Program With Dietary Counseling

Objectives: To check the responsiveness of plasma inflammatory marker and related NCDs to a short-length lifestyle-changing program aiming dietary adequacy.

Methods: Participants of the dynamic cohort of lifestyle-modification program (LiSM)"Move for Health" were submitted to a 10-wk LiSM with supervised physical exercises and dietary counseling. Before and after intervention they were assessed for 24h-food intake recall and calculations of Healthy-Eating Index(HEI) and intakes of single sugar (high CHO/Fiber), high sodium(Na/K) and low-dairy(Ca/protein). Assessments included anthropometry and plasma biochemistry for NCD diagnosis and high-sensitive C - reactive protein (hs-CRP) as inflammatory-stress marker ( >0.30 mg/dL). Data were compared for p=0.05.

Results: Inflammatory stress was more frequent in atherogenic dyslipidemia and liver fibrosis than in cases of fat dystrophies and sarcopenia. Frequency of inflammatory stress increased significantly in states of inadequate HEI, CHO/Fiber and Na/K. The conducted 10-wk LiSM decreased inadequate rates of HEI (24%), CHO/Fiber (17.2%), Na/K (14.3%) and Ca/Protein. The decreasing of fatness reduced abdominal (20.1%) and whole body (11.9) obesity, as well as the hs-CRP levels (37%) leading to 14.9% reduction of inflammatory -stress rate. These changes were paralleled by NCD reductions, ranked by highest risk of dislipemic, PAI (51.7%) and CHD (45.4%), T2D (31.4%) and dystrophic-dislipemic, NAFLD (26.8%) and MetS (19.4%).

Conclusions: The 10-wk LiSM with counseled-dietary adequacy was effective in reducing systemic inflammation and mostly relied NCDs.

Funding Sources: Cnpq 306640/2023-6