(P20-021-25) The Effects of a 12-Week Weight Management Program

Objectives: Managing a healthy weight is a growing challenge as the number of individuals who are overweight or obese increases throughout the world. Because of the importance of weight on overall health and wellbeing, strategies to support weight loss are in demand and of great value. A 12-week program was developed that includes an eating plan, physical activity, supplements, and meal replacement shakes. This program was designed to help support lean muscle while assisting with fat loss as well as other key needs around metabolism, appetite, and mood. The objective of this study was to assess the efficacy and safety of this 12w weight management program.

Methods: This was an open label clinical study with 64 men and women with BMI between 27.5 and 40kg/m². The subjects were asked to follow an eating plan, participate in physical activity, take 4 supplements to provide support for satiety, mood, and metabolism, and take 1 meal replacement daily for 12 weeks. Outcomes measured were body composition, hunger and appetite questionnaire, blood gene expression, and safety parameters (heart rate, blood pressure, and blood chemistries).

Results: The average change in weight from baseline after 14d was -1.3kg and -3.2kg at end of study (p < 0.001). After 12w, participants also had a significant reduction in body fat of -0.7kg (-2%, p=0.015) and a maintenance in skeletal muscle as measured by a full body electrical impedance device. Waist, thigh, upper arm, and ankle circumference measurements were all significantly reduced at the end of the study (p < 0.001). After 12w, most subjects reported decreased feelings of hunger, decreased desire to eat, decreased desire to eat something sweet, and did not want to eat again when asked two hours after lunch (p < 0.001). Blood gene expression was significantly impacted during the study. There were no serious adverse events reported, and the program was well tolerated.

Conclusions: This study demonstrates that this weight management program is safe, well tolerated, and effective.

Funding Sources: NSE Products, Inc., Provo, Utah