(P20-045-25) Effects of an Eight-Week Hydrogen-Rich Water Intervention on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-Like Peptide-1 Levels in Obese Adults

Objectives: Preliminary research suggests that dihydrogen (H₂) may influence molecular pathways associated with appetite regulation; however, its impact on patient-reported appetite outcomes in individuals with obesity remains unclear. This randomized, placebo-controlled, double-blind trial aimed to assess the effects of H₂ supplementation on appetite, body composition, sleep quality, obesity-specific quality of life, and related biomarkers in obese men and women.

Methods: The study enrolled 36 participants (24 females; mean age 42.1 ± 13.2 years, BMI 30.8 ± 4.2 kg/m²), who were randomized to receive either 1.0 L of hydrogen-rich water containing 15 mg of H₂ or 1.0 L of control water containing 0 mg of H₂ daily for eight weeks.

Results: The results indicated that hydrogen-rich water significantly reduced cravings (P = 0.05), improved subjective sleep quality (P = 0.05), decreased total cholesterol (P = 0.02) and LDL cholesterol (P = 0.04), and increased plasma glucagon-like peptide-1 levels (P = 0.05) compared to the control group. No serious adverse effects were reported during the trial.

Conclusions: These findings indicate that hydrogen-rich water may represent a safe and effective dietary intervention for regulating appetite and improving related metabolic parameters in individuals with obesity. The study is registered with ClinicalTrials.gov (NCT06722326).

Funding Sources: This study was partially funded by the Serbian Ministry of Science, Technological Development and Innovation, and Natural Wellness Now Health Products Inc.