(P20-051-25) Body Mass Index and Mortality in Hemodialysis Individuals: Evidence From a Brazilian Cohort Study

Objectives: To analyze the effects of body mass index (BMI) and age on cardiovascular disease mortality in individuals undergoing hemodialysis.

Methods: This retrospective cohort study analyzed sociodemographic, clinical, and nutritional data from 953 patients with chronic kidney disease on hemodialysis in Espírito Santo, Brazil, linked to mortality records from the Mortality Information System between 2019 and 2022. The analysis included Kaplan-Meier survival curves and the log-rank test to compare BMI and age groups. The Cox regression model was applied to simultaneously assess the influence of factors such as age, sex, time since diagnosis, education level, smoking status, and BMI on cardiovascular disease mortality. The study was approved by the UFES Ethics Committee (CAAE: 71289923.3.0000.5060).

Results: Eutrophic individuals exhibited higher survival rates, with significantly better survival curves over time, particularly among adults and older adults, compared to other BMI categories. Additionally, overweight individuals, both adults and older adults, showed lower survival rates. Among the covariates, the never smoked category was associated with a protective effect against the risk of death (p=0.0239), indicating a 38.4% reduction in mortality risk compared to the reference group (former smokers). Those with more than 11 years of education showed a 61.7% reduction in mortality risk (p=0.0467).

Conclusions: Hemodialysis patients with eutrophic BMI have higher survival rates, highlighting the importance of individualized interventions to improve the prognosis and quality of life of these individuals, considering their nutritional status and sociodemographic factors.

Funding Sources: This study was financially supported by EDITAL FAPES No. 28/2022.