(P13-021-25) Lower Amounts of Nuts, Fish, Vegetable Oil and Dairy Products Consumption Are Characteristic Features of Dietary Patterns in MASLD: Matched-Pairs Controlled Study

Objectives: Diet plays a crucial role in metabolic-associated steatotic liver disease (MASLD) development and treatment. Dietary interventions require better understanding of dietary patterns related to the disease presence. 

Aim of the study was to determine characteristics features of dietary patterns in patients with MASLD.

Methods: Nutrilogic (Nutrilogic LLC, Russia) database (more than 10 000 records) retrospective search was performed for complete and adequate data of nutritional assessment, related demographic and clinical characteristics of subjects >18 y.o. Diagnosis of MASLD was established per EASL guidelines and was supported by blood chemistry, vibration-controlled transient liver elastography with a controlled attenuation parameter in the absence of excessive alcohol intake and use of medications leading to fat accumulation. BMI-, age- and sex-matched pairs with no signs of MASLD were selected from the same cohort, neither of them was allocated for pair more than once. Diet was assessed using food frequency questionnaire (FFQ, 100 products blocked into 9 groups). Dietary patterns were assessed according to the method of the healthy eating index (HEI, 2021). Based on the patient's caloric intake obtained with the FFQ, the least squares method was used to obtain patient-specific adequate levels of food groups intake; the later were compared with those obtained from the patient.

Results: After selection, 77 matched pairs were eligible for the analysis. There was no difference between the MASLD and the control groups in terms of energy values of the rations, protein and carbohydrates intake. Greater consumptions of fat (83.7 [60.1; 119.1] vs 73.6 [55.6; 94.0] g/day; P=0.01) was detected in the MASLD group compared to the control.

Related to the HEI, patients with MASLD consumed less than recommended amounts of "fish and seafoods" (80% of the recommended intake), "nuts and seeds" (80%), "milk and dairy products" (40%), legumes (20%), vegetable oils (20%); and greater amounts of "meat, poultry, eggs" food group (120%).

Conclusions: The dietary pattern of patients with MASLD is characterized by lower than recommended intake of nuts, fish, vegetable oils, dairy products and excessive amounts of meat, poultry and eggs consumption.

Funding Sources: Ministry of Science and Higher Education research grant # FGMF-2025-0003