(P17-066-25) Oxidative Balance Score and Mortality Among Korean Women: Using the Korean Genome and Epidemiology Study (KoGES)

Objectives: Mortality can be affected by modifiable factors such as diet, smoking, drinking, and physical activity. This study aimed to evaluate the association between the oxidative balance score (OBS) and mortality among women using a large prospective cohort of Korean adults.

Methods: We analyzed 113,132 women participants aged 40–69 from the Korean Genome and Epidemiology Study (KoGES). Based on the questionnaire, the OBS was calculated from 13 prooxidant and antioxidant lifestyle factors, including smoking and drinking status, dietary intake, and physical activity with obesity. The participants were divided into three groups based on the tertiles of OBS. The risks of all and cause-specific mortality were estimated using a multivariable Cox proportional hazard regression model based on OBS tertiles. Women-specific factors, such as menopause, pregnancy, parity, and abortion, were included as potential confounders with demographic and lifestyle factors.

Results: During a mean of 6.62 ± 3.52 years follow-up, 2,415 deaths had occurred, including 1,162 due to cancer death (207 reproductive cancer deaths) and 425 due to cardiovascular disease (CVD). The risks of all and CVD mortality were inversely associated with the middle group of OBS tertiles (0.87, 0.78–0.96; 0.75, 0.59–0.97, respectively), but not in the highest one (0.82, 0.63–1.06). None of the OBS tertile groups was significantly related to cancer mortality.

Conclusions: Women with a middle tertile group of OBS were at lower risk for all and CVD mortality. No significant association was found between OBS and cancer mortality. Further research is needed to explore the association between antioxidants and the risk of cancer.

Funding Sources: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (RS-2023-00274347).