(P06-009-25) Skin-Condition-Improving Effects of a Formula Containing Ergothioneine, PQQ, and NR in Naturally Aging Asian Women: A Randomized Controlled Clinical Trial

Objectives: Ergothioneine can rapidly chelate metal ions and reduce the production of free radicals, which helps prevent DNA damage. Pyrroloquinoline Quinone (PQQ) and Nicotinamide Riboside (NR) stimulate the synthesis of mitochondria. All three substances have been reported to positively influence the NAD+ generation pathway, enhancing mitochondrial energy metabolism. However, there are no studies available that investigate the combination of these three ingredients for improving naturally aging skin. This study aimed to assess the cosmetic benefits of the formulation containing ergothioneine, PQQ, and NR through a clinical trial.

Methods: In a 56-day randomized, double-blind, placebo-controlled trial, 62 healthy Chinese women aged 36 to 60 were given oral supplements containing ergothioneine, PQQ, and NR. The subjects' skin condition indicators including skin moisture content, brightness, facial spots, elasticity, and pore size, were measured using specialized instruments. Additionally, questionnaires were used to assess skin stability, daily energy and memory status.

Results: At 14 days, subjects who received the formula containing ergothioneine, PQQ and NR showed a significant improvement in skin condition compared to those in the placebo group. Notable enhancements were observed in facial moisture content, skin barrier function, whitening, brightening, skin elasticity, and the appearance of wrinkles (P < 0.001). By 28 days, there was a significant reduction in facial pigmentation and the number of pores (P < 0.001). After 56 days, all measures of skin condition in the experimental group were superior to those in the placebo group (P < 0.001). Additionally, a questionnaire conducted at 56 days revealed that over 90% of participants reported improvements in subjective skin stability, daily energy levels, and memory.

Conclusions: Overall, these findings indicated that a formula containing ergothioneine, PQQ and NR may enhance skin health and boost daily vitality and memory in naturally aging Asian women.

Funding Sources: Heath and Happiness (H&H) China Limited